Early Fly Development
Research Interests
Our main research goal is to understand cell polarization. Specifically we want to understand polarization in the context of tissue morphogenesis and asymmetric mitotic division. We are also interested in germ line development as a model system to study cell totipotency and polarization.
* We are looking for highly enthusiastic postdoctoral researchers
Rui Martinho
Ph.D. in Biology
University of Sussex, Sussex
| Principal Investigator | |
|---|---|
| Phone | 21 440 7906 |
| Extension | 206 |
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| Location (Wing) | Zheng Ho (C1) - Room 1C9C |
Group Members
| Leonardo Guilgur | Postdoc |  |
|---|---|---|
| Tel: 21 446 4638 | |
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| Denisa Liszeková | Postdoc | |
| Tel: 21 440 7900 | |
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| Tânia Ferreira | External Ph.D. Student | |
| Tel: 21 446 4638 | |
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| Pedro Prudêncio | Laboratory Manager | |
| Tel: 21 446 4638 | |
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| Ana Rita Marques | 2006 PDIGC PhD Student | |
| Tel: 21 446 4638 | |
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| Ema Alves | Postdoc (ITQB) | |
| Tel: 21 446 4638 | |
Research Project
Analysis of early transcriptional activation and germ-line segregation in Drosophila melanogaster
Funding
Marie Curie International Reintegration Grant - 029165
Project coordinator: Rui Goncalo Viegas Russo C. Martinho
FCT Research grant (PTDC/BIA-BCM/69256/2006)
Project coordinator: Rui Goncalo Viegas Russo C. Martinho
FCT Research grant (POCI/DG/BIA/82013/2006)
Project coordinator: Rui Goncalo Viegas Russo C. Martinho
Publications
José Manuel de las Heras (*), Martinho, R.(*), Ruth Lehmann and Jordi Casanova (2009). A functional antagonism between the pgc germ-line repressor and torso in the development of somatic cells (*) equal contribution. EMBO reports (in press)
Rangan P., DeGennaro M., Jaime-Bustamante K. , Coux R., Martinho R.G., and Lehmann R. (2009). Temporal and spatial control of germ plasm RNAs. Current Biology 19 (1) :72-7
Pimenta-Marques, A., Tostões, R., Marty, T., Barbosa, V., Lehmann, R., Martinho, R.G. (*) (2008). Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Developmental Biology 323 (2) :197-206
Martinho, R.,G., Kunwar, P.S., Casanova, J., and Lehmann, R. (2004). A non-coding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. (This publication was featured in "Science Editor’s Choice" for highlights in recent literature; Science, vol. 303, Feb 6, 2004, and “Research Notes”; Nature Structural and Molecular Biology, vol. 11, Mar 2004). Current Biology, 14 (2) :159-165
Read, R.L., Martinho, R. G., Wang, S.W., Carr, A.M., and Norbury, C.J. (2002). Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest Proc Natl Acad Sci U S A, 99 (19) :12079-12084
Christensen, P.U., Bentley, N.J., Martinho, R. G., Nielsen, O, and Carr, A.M. (2000). Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis Proc Natl Acad Sci U S A, 14; 97 :2579-2584
Martinho, R. G. and Carr, A.M. (1999). Isolation of DNA structure-dependent Checkpoint Mutants in S. pombe DNA repair protocols"-Methods in Molecular Biology. Humana Press Inc.
Martinho, R. G., Lindsay, H.D., Flaggs, G., DeMaggio, A.J., Hoekstra, M.F., Carr, A.M., and Bentley, N.J. (1998). Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses EMBO J. 17 (24) :7239-7249
Martinho, R. G., Castel, S., Urena J., Fernandez-Borja, M., Makiya, R., Olivecrona, G., Reina, M., Alonso A. and, Vilaro, S. (1996). Ligand binding to Heparan Sulfate Proteoglycans Induces Their Aggregation and Distribution along Actin Cytoskeleton Mol Biol Cell 7 (11) :1771-1788