Desenvolvimento em Mosca

Interesse da Investigação

Drosophila early embryonic development is rapid and well coordinated, with a series of extremely fast syncytial nuclei divisions, segregation of the germ-line, de novo activation of the zygotic genome, synchronous formation of thousands of epithelial cells, and ultimately, gastrulation and germ-band extension. Remarkably, and although these events are interdependent and stereotypical, at cellular level there is a significant degree of phenotypic plasticity.
Our goal is to better understand Drosophila early embryonic development as a model system for global regulation of gene expression and germ-line development, tissue morphogenesis, and ultimately phenotypic plasticity and biological robustness.

* We are looking for highly enthusiastic postdoctoral researchers

Membros do Grupo

Leonardo Guilgur	Postdoc
	Tel: 21 446 4638
Denisa Liszeková	Postdoc
	Tel: 21 440 7900
Tânia Ferreira	External Ph.D. Student
	Tel: 21 446 4638
Pedro Prudêncio	Laboratory Manager
	Tel: 21 446 4638
Ana Rita Marques	2006 PDIGC PhD Student
	Tel: 21 446 4638

Projecto de Investigação

Analysis of early transcriptional activation and germ-line segregation in Drosophila melanogaster

Funding

Marie Curie International Reintegration Grant - 029165
Project coordinator: Rui Goncalo Viegas Russo C. Martinho

FCT Research grant (PTDC/BIA-BCM/69256/2006)
Project coordinator: Rui Goncalo Viegas Russo C. Martinho

FCT Research grant (POCI/DG/BIA/82013/2006)
Project coordinator: Rui Goncalo Viegas Russo C. Martinho

Publicações

de las Heras, J.M. (*), Martinho, R.(*), Ruth Lehmann and Jordi Casanova (2009). A functional antagonism between the pgc germ-line repressor and torso in the development of somatic cells (*) equal contribution. EMBO reports 10 (9) :1059-65.

Rangan P., DeGennaro M., Jaime-Bustamante K. , Coux R., Martinho R.G., and Lehmann R. (2009). Temporal and spatial control of germ plasm RNAs. Current Biology 19 (1) :72-7

Pimenta-Marques, A., Tostões, R., Marty, T., Barbosa, V., Lehmann, R., Martinho, R.G. (*) (2008). Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Developmental Biology 323 (2) :197-206

Martinho, R.,G., Kunwar, P.S., Casanova, J., and Lehmann, R. (2004). A non-coding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. (This publication was featured in "Science Editor’s Choice" for highlights in recent literature; Science, vol. 303, Feb 6, 2004, and “Research Notes”; Nature Structural and Molecular Biology, vol. 11, Mar 2004). Current Biology, 14 (2) :159-165

Read, R.L., Martinho, R. G., Wang, S.W., Carr, A.M., and Norbury, C.J. (2002). Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest Proc Natl Acad Sci U S A, 99 (19) :12079-12084

Christensen, P.U., Bentley, N.J., Martinho, R. G., Nielsen, O, and Carr, A.M. (2000). Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis Proc Natl Acad Sci U S A, 14; 97 :2579-2584

Martinho, R. G. and Carr, A.M. (1999). Isolation of DNA structure-dependent Checkpoint Mutants in S. pombe DNA repair protocols"-Methods in Molecular Biology. Humana Press Inc.

Martinho, R. G., Lindsay, H.D., Flaggs, G., DeMaggio, A.J., Hoekstra, M.F., Carr, A.M., and Bentley, N.J. (1998). Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses EMBO J. 17 (24) :7239-7249

Martinho, R. G., Castel, S., Urena J., Fernandez-Borja, M., Makiya, R., Olivecrona, G., Reina, M., Alonso A. and, Vilaro, S. (1996). Ligand binding to Heparan Sulfate Proteoglycans Induces Their Aggregation and Distribution along Actin Cytoskeleton Mol Biol Cell 7 (11) :1771-1788