Neurobiologia da Acção

Interesse da Investigação

We study the neurobiology of action in health and disease.
To study actions is to study the way we do things, which is different than studying how we remember stimuli, or facts and events. Some actions are innate or pre-wired (like swallowing, breathing, even grooming). Others are learned through trial and error throughout life. We currently focus on understanding the processes mediating the latter.
Our overall goal is to understand how changes in molecular networks in the brain modify neural circuits to produce experience-dependent changes in actions. In order to understand how actions are learned through trial and error, we subdivided our experiments in different components, or specific goals:

Action initiation: how do we initiate and generate diverse actions (trial),
Action improvement: how do we improve the accuracy and speed of actions (through trial and error), and.
Actions and outcomes: how do we learn that particular actions lead to particular outcomes (goal of the action) and how do we form habits.

A growing body of evidence supports an important role of the basal ganglia in action initiation and selection, in skill learning, and in learning goal-directed actions and habits. Therefore, we centered our efforts on investigating the cortico-basal ganglia mechanisms underlying these three processes using an across-level approach, from molecules to circuits.
We chose to implement this integrative approach in mice because they combine the power of genetics, a mammalian brain with canonical cortico-basal ganglia loops that can generate and propagate oscillatory activity, and the possibility of accurately quantifying simple behaviors like action initiation (with EMG recordings or using inertial sensors) and stereotypic skill learning, and more elaborate behaviors like goal-directed actions.
Our research program will hopefully shed light on the mechanisms underlying the diversity of actions we perform, the automatization of actions and the generalization of rules or ways to do. Our research may also have important implications for understanding the relation between corticostriatal dysfunction and the symptoms of different neurodegenerative and psychiatric disorders.

Membros do Grupo

Catherine French	Postdoc
	Tel: 21 446 670
Fatuel Aguilar	Postdoc
	Tel: 21 446 4670
Cristina Afonso	Postdoc
	Tel: 21 446 4670
John Burkhardt	Postdoc
	Tel: 21 446 4670
Gabriela Martins	Postdoc
	Tel: 21 440 7900
Eduardo Ferreira	External Ph.D. Student
	Tel: 21 440 7900
Vitor Paixão	Informatics Technician
	Tel: 21 446 4670
Pedro Ferreira	2007 PGCN PhD Student
	Tel: 21 446 4670
Fernando Santos	2008 PGCN PhD Student
	Tel: 21 440 7900
Ana Mafalda Vicente	2008 PGCN PhD Student
	Tel: 21 446 4611
Rosalina Fonseca	Clinical Research Fellow
	Tel: 21 446 4670

Publicações

(Selected) Update November (2009).

Dias-Ferreira, E., Sousa, J.C., Melo I., Morgado P., Mesquita, A.R., Cerqueira J.J., Costa, R.M. Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making Science 325(5940) :621-5

Yin, H.H., Prasad-Mulcare, S., Hilario, M.R., Clouse, E., Davis, M. I., Hansson, A., Lovinger, D.M., Costa, R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill Nature Neuroscience 12 :3

Hilario, M.R. and Costa, R.M. (2008). High on Habits Frontiers in Neuroscience 2,2 :208-21

Cui, Y., Costa R. M., Murphy G. G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning Cell 31;135(3) :549-60

Hilario, M.R., Clouse, E., Yin, H.H., Costa, R.M. (2007). Endocannabinoid signaling is critical for habit formation Frontiers in Integrative Neuroscience 1 :6

Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr, M., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction Neuron 52(2) :359-69

Costa, R.M., Drew, C. and Silva, A.J. (2005). Notch to Remember Trends in Neurosciences 28 :429-35

Costa, R.M.*, Cohen, D.*, Nicolelis M.A.L. (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice Current Biology 14(13) :1124-34

Costa R.M., Honjo T., and Silva A.J. (2003). Learning and memory deficits in Notch mutant mice Current Biology 13 (15) :1348-54

Costa, R.M. and Silva, A.J. (2003). Mouse models of Neurofibromatosis type I: Bridging the GAP Trends in Molecular Medicine 9 :19-23

Costa, R.M., Federov, N.B., Kogan, J.H., Murphy, G.G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 Nature 415 (6871) :526-30

Costa, R.M.*, Yang, T.*, Huynh, D.P., Pulst S.M., Viskochil, D.H., Silva, A.J. and Brannan, C.I. (2001). Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene Nature Genetics 27 :399-405